Surface-wave-based optical sensing of an analyte in a fluid relies on the sensitivity of the surface wave to the electromagnetic properties of the analyte-containing fluid in the vicinity of the guiding interface. Surfaceplasmon-polariton (SPP) waves are most commonly used for optical sensing because of the ease of the excitation of an SPP wave when the fluid is partnered with a metal. If the fluid is replaced by a porous, anisotropic, and periodically nonhomogeneous solid filled with the fluid, while the metal is replaced by an isotropic homogeneous dielectric material, the surface wave is called a Dyakonov–Tamm (DT) wave. We have theoretically determined that the incorporation of the DT-waveguiding interface in a prism-coupled configuration provides an alternative to the analogous SPP wave-based sensor, with comparable dynamic sensitivity.